Evaluation of spermicidal potential of labdane diterpenes from Andrographis paniculata
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منابع مشابه
Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14...
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Five new labdane diterpenes (1-5) together with seven known diterpenes have been isolated from a methanol extract of the aerial parts of Aster oharai. Five new structures were determined as 7alpha-hydroperoxylabda-8(17),14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (1), 7alpha-hydroperoxylabda-8,14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (2), labda-7,14-dien-13(R)-ol-4-...
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Andrographis paniculata (Burm.f.) Nees (Acanthaceae), a plant widely used as traditional herbal medicine in many countries, has drawn attention of the researchers in recent years. Its major constituents are diterpenoids and flavonoids. This article reviews the anti-hepatotoxic effects of A. paniculata extract and derivative compounds, such as andrographolide, the major active compound, most stu...
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Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1-4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds we...
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Andrographolide isolated from Andrographis paniculata Ness (A and 1.40 mM induced DNA fragmentation and increased the percentage o breast cancer cell line was treated for 24 , 48 and 72 h. The results de induce apoptosis in TD-47 human breast cancer cell line in a time and increase expression of p53, bax , caspase-3 and decrease ex immunohistochemical analysis.
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ژورنال
عنوان ژورنال: International Journal of Biological and Chemical Sciences
سال: 2009
ISSN: 1991-8631
DOI: 10.4314/ijbcs.v3i4.47170